the morphological changes indicative of cell death caused by enzymatic degradation. aseptic necrosis necrosis without infection or inflammation. acute tubular necrosis acute renal failure with mild to severe damage or necrosis of tubule cells, usually secondary to either nephrotoxicity, ischemia after major surgery, trauma (see crush syndrome), severe hypovolemia, sepsis, or burns. Balser's fatty necrosis gangrenous pancreatitis with omental bursitis and disseminated patches of necrosis of fatty tissues. bridging necrosis septa of confluent necrosis bridging adjacent central veins of hepatic lobules and portal triads characteristic of subacute hepatic necrosis.