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PCSK9 Inhibitor/Statin Combo for ASCVD?


Journal of the American Medical Association - August 16, 2016 PCSK9抑制剂/他汀类组合用于治疗杂合子家族性高胆固醇血症或粥样硬化性心血管疾病的可能性。 Possible combination of PCSK9 inhibitors with statins in heterozygous familial hypercholesterolemia or atherosclerotic cardiovascular disease.

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Catherine Dolf, Reporter, The JAMA Report: Millions of people struggle to lower their LDL, or "bad cholesterol". A new type of therapy called a "PCSK9 inhibitor" can help reduce LDL - or bad cholesterol - by nearly 50%.
Dr. Dhruv Kazi, Assistant Professor, UCSF:
They block a specific enzyme in the cholesterol pathway. In doing so, they increase the removal of LDL cholesterol from the blood into the liver, and lower LDL cholesterol levels.
Dr. Kirsten Bibbins-Domingo, Professor, UCSF: They were approved to be used for individuals who are at higher risk for heart disease, who have had a heart attack, a stroke, or who have a family history of very high cholesterol. These drugs were approved to be used in addition to the statin medications in these particular individuals.
CD: Doctors Kirsten Bibbins-Domingo and Dhruv Kazi from the University of California San Francisco, and their co-authors, examined the cost effectiveness of PCSK9 inhibitors and their potential effect on U.S. healthcare spending. Using a simulation model that included all U.S. adults aged 35 and older, they evaluated outcomes like expected number of deaths due to cardiovascular disease, heart attacks and strokes, and balanced this with the cost and potential benefits of these drugs. The authors estimated that about 9 million people would be eligible for this therapy.
DK: This innovation comes at a price. They were launched at a little over $14,000 per patient per year.
KBD: It would increase our total expenditure on prescription drugs by almost 40%.
CD: The study appears in JAMA - Journal of the American Medical Association.
DK: All healthcare expenses would go up 4%, and that's a large increase in our total U.S. healthcare expense, based on one set of drugs alone.
KBD: Our analysis suggests that that price tag should be closer to just over $4,000 a year for them to be cost-effective.
DK: Should that not happen, we would expect to see an unprecedented strain on health system budgets across the country.
CD: Catherine Dolf, The JAMA Report.

  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    across the country 全国范围
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    aging 老化【及物动词】衰老,老龄化,时效,老龄,增龄,陈酿,老年
  • American Medical Association 美国医学协会◆【略】AMA
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    author 作者【名词】1. 著者,作家; 2. 著作物,作品; 3. 创造者;发起人; 【及物动词】1. 写,写作; 2. 创造,创始; 3. 【自动化】(在计算机上)制作(网页)
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    benefit 【名词】1. 利益,好处;利润 2. 恩惠 3. 义演,义赛; 4. 退休金;(依照社会保险付给的)津贴,救济金,抚恤金; 5. (俚、反)好机会,好差事; 【及物动词】对…有利,有益于…;使得利益; 【不及物动词】得益,受益
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    blood 血液【名词】1. 血,血液;生命液; 2. 血族,血统;种族;家族(关系);家世;门第;名门,门阀;贵族血统; 3. 生命,活力;元气; 4. 流血,杀戮,杀人(罪),牺牲; 5. 血气;气质,气性,脾气;热情;激怒;肉欲;兽欲; 6. (主英)血气方刚的人;花花公子,纨袴子; 7. (集合词)人员; 8. (树木、果子等的)赤色汁液;(美俚)蕃茄酱; 9. (马的)纯种
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    budget 预算 【名词】1. 预算,预算案。; 2. 经营费;生活费;(有限制的)供应,来源。; 3. (古语)(方言)小皮包;小皮包中的东西。; 4. (比喻)(书信等的)一束,一捆;(要闻)汇编(作报名用)。; 预算 【及物动词】1. 把…编入预算;按预算来安排(生活、工程等)。; 预算 【不及物动词】1. 编预算。; 2. 作好安排。
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    cardiovascular 心血管的
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    cardiovascular disease 心血管疾病◆【略】CVD
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    cholesterol 胆固醇;胆甾醇
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    cholesterol level 胆固醇水平
  • cholesterol pathway 胆固醇(代谢)途径
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    clinical outcome 临床结果;临床疗效; 临床转归
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    co-author 合著者;合著
  • cost effectiveness 成本效益;费用效益
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    cost-effective 成本效益
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    disease 【名词】1. 病,疾病;【植物】病害 2. (精神等的)病态,弊病 3. (酒等的)变质;(食物等的)腐败
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    drugged 【及物动词】用药麻醉;使服药;使服毒品
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    effective 有效【形容词】1. 有效(力)的,灵验的;显眼的,(美国)生效的,被实施的;【军事】有战斗力的; 2. 【经济学】实质上的;有实价的; 3. 【军事】精锐的
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    effectiveness 有效性;效果;效能
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    eligible 【形容词】1. 合格的,合适的;符合条件的;有资格的 【名词】 合格者;适任者;有资格者
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    enzyme
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    estimate 估计 【及物动词】1. 估计,估算;估价;估量; 2. 评价,评断; 3. (古语)尊重; 【不及物动词】估计,估价; 【名词】1. 估计; 预测;(英国) (pl.)预算,预算额;预算书;估价单;(从典型统计得出的)数值; 2. 评价,判断
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    evaluate 评价【及物动词】1. 对…估价,对…作评价; 2. 【数学】求…的值
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    examine 【及物动词】1. 检查,细查; 仔细观察 2. (估价健康状况或确诊病因而)检查 3. 查问,调查 4. 或考试,测验 5. 【法律】审查,审讯 6. 【医】送交剖检【不及物动词】进行检查(或审查、调查、考试); 讯问
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    expenditure 支出【名词】1. (时间、劳力、金钱等的)支出,花费; 2. 消费;开销;费用,经费; 3. 支出额,消费额
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    expense 费用【名词】1. (时间、精力、金钱等的)消耗,花消,消费; 2. (无形的)损失;牺牲; 3. (常 pl.)费用;(额外)开支; 4. 费钱的东西
  • Extracting Microarray Gene Expression Patterns and Identifying co-expressed Genes 提取微阵列基因表达模式和确认共表达基因◆【略】EPIG
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    family history 家族史
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    health system 卫生系统
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    healthcare 医疗保健;医疗卫生;健康服务
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    healthcare expense 医疗费用
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    healthcare spending 医疗费用
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    heart 心 【名词】1. 心脏,心; 2. 胸,胸部;心胸,心地,心肠,胸怀; 3. 感情,热情,爱情;灵魂;良心; 4. 勇气,胆力;勇士; 5. 精神,气质;心境,心情; 6. 中心,核心;精华,要点,本质; 7. 意中人,情人;心爱的人,宝贝儿; 8. (主英)(土地的)肥沃程度; 9. 心脏形的东西
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    heart attack 心脏病发作
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    heart attack and stroke 心脏病发作和卒中
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    heart disease 心脏疾病
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    high cholesterol 高胆固醇
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    inhibitor 抑制剂【名词】抑制因子,缓蚀剂,阻垢剂
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    innovation 创新【名词】创新,革新;改革;新设施,新方法,新发明
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    liver 肝【1名词】1. 【解剖学】肝脏; 2. (食用)肝; 3. 赤褐色; 【2名词】生活者;居住者
  • low-density lipoprotein cholesterol 低密度脂蛋白胆固醇◆【略】LDL-C
  • low-density lipoprotein cholesterol level 低密度脂蛋白胆固醇水平◆【略】LDL
  • lower low-density lipoprotein cholesterol 降低低密度脂蛋白胆固醇◆【略】LDL
  • lower low-density lipoprotein cholesterol level 降低低密度脂蛋白胆固醇水平◆【略】LDL
  • medical association 医学协会
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    medical journal 医学期刊
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    medication 【名词】1. 药物疗法,加入药物,药物处理,用药物治;2. 药物,药剂
  • number of deaths 死亡人数
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    particular 特别是【形容词】特定,特别,特殊,特别是,尤其是,尤其,具体,个别,独特,某
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    pathway 途径;路径;通路
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    potential 潜力【形容词】1. 可能的;【语法】可能语气的; 2. 潜在的;有潜势的;【物理学】位的,势的; 3. (罕用语)有力的; 【名词】1. 可能(性);【语法】可能语气; 2. 潜在力;潜势;【物理学】位,势;电势,电位
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    potential benefit 可能的益处
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    prescription 【名词】1. 处方;处方的药;解救方法 2. 命令;规定;法规 3.【法律】(由于长期使用等而)获得权利 【形容词】按处方配制的◆【対】over-the-counter (OTC)
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    prescription drug 处方药
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    price tag 标价
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    professor 教授【名词】1. (大学)教授(略 Prof.);(男性)先生,老师; 2. (俚、谑)(魔术、拳击、跳舞等的)专家; 3. 声明者;自称者;表白信仰者; 4. (在酒吧间等处)下等场所弹奏钢琴者
  • proprotein convertase subtilisin/kexin type 9 inhibitor 前蛋白转化酶枯草溶菌素9抑制剂◆【略】PCSK9
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    removal 去除【名词】脱除,除,清除,拆除,搬迁,切除,移除,除去,删除,消除
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    setting 【名词】1. 设置; 设定; 安装 2. 环境;背景; 布置
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    simulation 模拟【名词】仿真
  • simulation model 模拟模型
  • specific enzyme 特定的酶
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    statin drug 他汀类药物
  • statin medication 他汀类药物
  • straining 紧张
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    stroke 【名词】1. 脑卒中;中风;(疾病的)发作 2. (心脏的)跳动;脉搏 3. 一击,一敲 4. 【机械】冲程,行程【1及物动词】1. (用笔)画;勾消 2. (划船比赛中) 划【2及物动词】轻抚
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    struggle 【名词】 挣扎,努力,拼搏,斗争; 【不及物动词】挣扎,努力,奋斗; 【及物动词】努力使得
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    The Journal of the American Medical Association 《美国医学协会杂志》◆【略】JAMA
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    therapy 【名词】疗法;疗效
  • total expenditure 总支出
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    unprecedented 前所未有【形容词】1. 没有前例的,空前的;无比的; 2. 新奇的;崭新的
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    very high cholesterol 非常高的胆固醇水平
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