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Can Immunotherapy Affect Cognitive Function?


Cancer Research Institute - May 19, 2016 回答患者急需了解的肿瘤免疫治疗问题。 Answering urgent patient questions about cancer immunotherapy.

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Dr. David Reardon, Clinical Director, Dana-Farber Cancer Institute: As clinicians who are treating patients with brain cancer, we have a very high priority on not only helping our patients live longer, but [also] helping them to live well. And a very important aspect of living well for patients with brain cancer is being able to maintain their brain function, which means being able to think and keep track of things, and to interact effectively, and to do all the things we want to do and that are important to us on a day-to-day basis. Immunotherapies, in general, we would not expect would impact on the brain's function in a negative way, particularly our ability to think and process information and keep track of things and respond effectively and remember. Immunotherapies, we wouldn't not expect to have a detrimental effect on those types of function of the brain. Unfortunately though, the tumor - the fact that it's there - and then, some of the other treatments that are traditionally and typically [have] been used, whether it be surgery, radiation therapy or chemotherapy, can have an impact on some of those aspects of brain function. And particularly, cognitive functions [such as] thinking and keeping track of things. So, it can be very difficult to tease out, if patients are experiencing frustrations or difficulties along those lines, what the actual cause is. But in general, we would not expect immunotherapies to contribute or to make those things worse.

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    along those lines 按照这种思维
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    brain 大脑【名词】1. 脑,(pl.)脑髓;(俚语)计算机;(导弹的)制导系统; 2. (常 pl.)智力,智能,智慧,脑力;头脑; 3. (口语)聪明人;(口语)(pl.)智囊,出谋划策者
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    brain cancer 脑癌;恶性脑肿瘤
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    brain function 脑功能
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    cancer 癌症【名词】1. 癌症;癌(瘤),肿瘤; 2. 弊病;社会恶习; 3. (the C-)【天文学】巨蟹座;巨蟹宫
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    cancer institute 癌症研究所
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    chemotherapy 化学疗法;化疗
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    clinical 临床【形容词】疗效,临床医学
  • clinical director 临床主任
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    clinician 临床医生
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    cognitive 认知【形容词】认识的,有认识力的
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    cognitive function 认知功能
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    contribute 贡献【及物动词】1. 捐赠(款项); 2. 投稿(给杂志等); 3. 贡献出; 【不及物动词】1. 出力,作出贡献; 2. 捐款,捐献; 3. 投稿
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    detrimental 有害的; 不利的
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    detrimental effect 有害影响
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    director 主管【名词】1. 指挥者,监督人,管理人; 总监;院长;所长;主任 2.理事,董事;经理 3. 【戏剧】导演【音乐】指挥 4. 引向器; 指示器; 导向偶极子
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    effectively 有效【副词】1. 有效地,有力地; 2. 实际上
  • Extracting Microarray Gene Expression Patterns and Identifying co-expressed Genes 提取微阵列基因表达模式和确认共表达基因◆【略】EPIG
  • frustration 挫折
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    high priority 最优先的考虑
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    immunotherapy 免疫治疗【名词】免疫疗法
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    institute 研究所【名词】1. 协会,学会;学院,专科大学;(学院附设的)研究所; 2. 讲习会;(短期)训练班; 3. 会址,院址,校址,所址; 4. 原则,规则,惯例; 5. (给初学者用的法律、医学等的)浅说,(公认的)基本原理; 【及物动词】1. 设,设立,制定; 2. 实行,创立,开始; 3. 任命,【宗教】授…以圣职
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    interact 交互【不及物动词】相互作用,相互影响,互动
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    keep track 通晓事态; 注意事情进程
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    keep track of 通晓事态; 注意事情进程
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    lining 衬砌【名词】衬里,内衬,衬砌结构,面料,衬板;【及物动词】衬,炉衬,衬套
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    negative 阴性的;否定的;负的【形容词】负面,消极,阴性,否定,负数,负值,不利,负极,反面,不良
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    on a day-to-day basis 日复一日;日常事务
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    priority 优先【名词】优先级,优先权,优先考虑,优先事项,优先次序,当务之急,重点,首要
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    radiation 【医学】射线疗法【名词】1. 放射;辐射;发光 2. 【物理学】辐射;放射物;辐射线[热、能];照射(作用); 3. 【动、植】辐射形
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    radiation therapy 放射治疗
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    surgery 【名词】1. 外科(学);外科手术; 2. 外科手术[实验]室;(英国)医院;诊所
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    tease out 从…理出; 分解出
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    therapy 疗法;疗效
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    treated patient 治疗的患者
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    treatment 【名词】1. 治疗;疗法;疗程 2. 对待;处理 3.评述
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    tumor 肿瘤;肿块;赘生物
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    very high priority 极为优先的考虑
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