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Therapeutic Substitution Offers Huge Savings


Journal of the American Medical Association - May 9, 2016 新研究估算治疗性替代药物会带来惊人的费用节省。 A new study estimates potential windfall from therapeutic substitutions of branded drugs with generics in the same class.

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Catherine Dolf, Reporter, The JAMA Report: This pharmacy is filled with thousands of different medications. Some are brand-name, some are generic, and some can be used in a process known as "therapeutic substitution".
Dr. Michael Johansen, Family Medicine Specialist, Ohio State University: This is theoretically different than generic drugs. Generic drug substitution is substitution of the exact same drug. Therapeutic substitution is the use of a similar, but not the same, drug within a drug class.
CD: Dr. Michael Johansen from The Ohio State University, along with his colleague, reviewed the records of more than 107,000 patients between 2010 and 2012. They looked at prescription drug use and estimated how much money could be saved using therapeutic substitution.
MJ: There are 26 included drug classes, that spanned cardiovascular health, mental health, allergies, urology, and many other aspects of medicine. 62% of people in the United States use prescription drugs. Around one-third of people took a drug from the included classes.
CD: The study appears in JAMA Internal Medicine.
MJ: In total, $73 billion over three years - or nearly one out of every $10 spent on prescription drugs - could have been saved with therapeutic substitution. Importantly, the consumer paid just over one-third, or $24.6 billion of the total $73 billion that could have been saved.
CD: Dr. Johansen says that therapeutic substitution is somewhat controversial, because it could impede decisions about medications that are made between doctors and patients.
MJ: There is tremendous potential savings from undertaking of therapeutic substitution on a large scale. However, therapeutic substitution is controversial. It needs to be done in a respectful manner of patients health because that's really what we're here for, is to try to make patients healthier.
CD: Catherine Dolf, the JAMA Report.

  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    allergy 【名词】过敏性;过敏症;变态反应性
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    brand name 品牌名称;商品名;商标名称
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    cardiovascular 心血管的
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    cardiovascular health 心血管健康
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    colleague 同事【名词】同事,同行
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    consumer 【名词】1. 消费者,用户 2. 用电设备 3. 【生物学】消费有机体
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    controversial 有争议【形容词】1. (有)争论的,被争论的; 2. 好争论的
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    different medication 不同的药
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    drug class 药物分类
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    drug substitution 药物替代
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    drugged 【及物动词】用药麻醉;使服药;使服毒品
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    estimate 估计 【及物动词】1. 估计,估算;估价;估量; 2. 评价,评断; 3. (古语)尊重; 【不及物动词】估计,估价; 【名词】1. 估计; 预测;(英国) (pl.)预算,预算额;预算书;估价单;(从典型统计得出的)数值; 2. 评价,判断
  • Extracting Microarray Gene Expression Patterns and Identifying co-expressed Genes 提取微阵列基因表达模式和确认共表达基因◆【略】EPIG
  • family medicine 家庭医学
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    generic 【名词】仿制药; 【形容词】1. 【生物学】属的,类的; 2. 一般的,普通的; 3. (商品)未注册的;不受商标注册保护的; 4. 【语法】全称的,总称的
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    generic drug 仿制药; 非专利药; 通用名药
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    generic drug substitution 仿制药替代; 通用名药物间替代
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    impede 阻碍【及物动词】妨碍,阻止
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    internal medicine 内科学
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    medication 【名词】1. 药物疗法,加入药物,药物处理,用药物治;2. 药物,药剂
  • mental 精神上
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    mental health 精神卫生;精神健康;心理健康
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    Ohio 俄亥俄州
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    on a large scale 大规模的
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    pharmacy 药房 【名词】1. 配药学,药学; 2. 制药业; 3. 药房; 4. (一批)备用药品
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    potential 潜力【形容词】1. 可能的;【语法】可能语气的; 2. 潜在的;有潜势的;【物理学】位的,势的; 3. (罕用语)有力的; 【名词】1. 可能(性);【语法】可能语气; 2. 潜在力;潜势;【物理学】位,势;电势,电位
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    prescription 【名词】1. 处方;处方的药;解救方法 2. 命令;规定;法规 3.【法律】(由于长期使用等而)获得权利 【形容词】按处方配制的◆【対】over-the-counter (OTC)
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    prescription drug 处方药
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    prescription drug use 处方药使用
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    savings 储蓄【名词】积蓄,节省,节约,存款,储蓄存款
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    scaling 缩放; [口腔] 刮牙术
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    specialist 专家◆【略】GP◆【参考】general practitioner
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    substitution 替代【名词】代换,替换,取代,换人,置换,代用,代替,替补,替代品
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    The Journal of the American Medical Association 《美国医学协会杂志》◆【略】JAMA
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    theoretical 从理论上讲【形容词】1. 理论(上)的,学理上的; 2. 假设(性)的;纯理论的,推理的; 3. 空论的
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    theoretically different 理论上不同的
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    therapeutic 治疗的,治疗(学)的,疗法(上)的
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    therapeutic substitution 治疗性替代
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    tremendous 巨大【形容词】可怕的,惊人的;(口语)巨大的;(俚语)极好的,非常巧妙的(手段等)
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    tremendous potential savings 大笔节省费用的可能性
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    undertake 【及物动词】1. 从事,着手进行, 担任(工作等); 2. 同意,约定,保证
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    urology 泌尿学
Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615