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Mapping High Blood Pressure Path


Cleveland Clinic - February 24, 2016 识别控制水-盐平衡调节血压的关键酶。 Identifying the enzyme that controls corin, a water-salt regulator crucial to hypertension.

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Announcer: Identification of an enzyme essential for normal blood pressure
Narrator: Dr. Qingyu Wu first discovered corin and its role in 1999. Corin is an enzyme in the heart muscle. When blood pressure is high, corin converts the inactive hormone atrial natriuretic peptide - or "ANP" - into its active form. ANP then regulates the body's sodium and water balance needed for healthy blood pressure and heart function. When corin is defective, it fails to activate ANP, and hypertension occurs.
Dr. Qingyu Wu, Cardiologist, Cleveland Clinic: We found that one of the defects is caused by lack of activation. And obviously, another enzyme acts on top of this enzyme, and so we set out to find this missing enzyme.
Narrator: Dr. Wu identified the missing enzyme as "PCSK6". When removed in mice, the mice developed hypertension.
QW: This discovery allowed us to develop diagnostic tests, and ultimately, develop certain products to treat patients with heart failure.

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    activated 激活【及物动词】1. 使活动,开动,起动,触发;创设,成立(机构等); 2. 【化学】激活;活化; 3. 【物理学】赋能;使产生放射性; 4. 使(阴沟)产生微生物(而加以净化)
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    activation 激活【名词】 激活,活化(作用)
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    active form 活化型;激活型
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    an enzyme essential for normal blood pressure 维持正常血压至关重要的酶
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    another enzyme acts on top of this enzyme 作用于激活这种酶的另一种酶
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    atrial 【形容词】心房的;(眼)前房的
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    atrial natriuretic peptide 心房利钠肽;心钠素;心房钠尿肽
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    blood 血液【名词】1. 血,血液;生命液; 2. 血族,血统;种族;家族(关系);家世;门第;名门,门阀;贵族血统; 3. 生命,活力;元气; 4. 流血,杀戮,杀人(罪),牺牲; 5. 血气;气质,气性,脾气;热情;激怒;肉欲;兽欲; 6. (主英)血气方刚的人;花花公子,纨袴子; 7. (集合词)人员; 8. (树木、果子等的)赤色汁液;(美俚)蕃茄酱; 9. (马的)纯种
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    blood pressure 血压◆【略】BP
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    cardiologist 心脏病学家;心血管病医师
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    Cleveland Clinic 克利夫兰诊所
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    clinic 诊所【名词】1. 临床讲授;临床实习课; 2. 诊所;门诊部; 3. 特殊病例分析;会诊
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    corin 心房利钠肽转化酶
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    defect 缺陷【名词】1. 缺陷,缺点,弱点;短处; 2. 不足,缺乏; 【不及物动词】叛变;逃走
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    defective 有缺陷【形容词】1. 有缺陷[缺点]的,有瑕疵的,不完全的; 2. 【语法】变化不全的; 3. 智力低于正常的; 【名词】1. 身心有缺陷的人; 2. 变化不全的词
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    diagnostic test 诊断性测试
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    diagnostics 【名】1. 《医》診断(器具); 2. 〔病気の〕兆候、特徴; 3. 診断法
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    discovery 发现【名词】1. 发见,发现,发觉; 2. 【法律】(审判前当事一方必须作出的)显示证据; 3. (古语)显示,暴露,显露; 4. (剧情的)发展; 5. 被发现的事物
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    enzyme
  • Extracting Microarray Gene Expression Patterns and Identifying co-expressed Genes 提取微阵列基因表达模式和确认共表达基因◆【略】EPIG
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    failure 失败【名词】衰竭,失效,故障,失灵,破坏,衰,失败者,失误
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    finding 【名词】1.发现,发现物,调查的结果,研究结果; 2. 裁决,定罪 【动词原形】find
  • healthy blood 健康的血
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    healthy blood pressure 健康血压水平
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    heart 心 【名词】1. 心脏,心; 2. 胸,胸部;心胸,心地,心肠,胸怀; 3. 感情,热情,爱情;灵魂;良心; 4. 勇气,胆力;勇士; 5. 精神,气质;心境,心情; 6. 中心,核心;精华,要点,本质; 7. 意中人,情人;心爱的人,宝贝儿; 8. (主英)(土地的)肥沃程度; 9. 心脏形的东西
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    heart failure 心脏衰竭;心力衰竭
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    heart function 心脏功能
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    heart muscle 心肌
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    hormone 激素【名词】荷尔蒙,激素,内分泌
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    hypertension 高血压【名词】1. 高血压; 2. 过度紧张
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    identification 识别;确认
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    inactive hormone 无活性激素
  • lack 【及物/不及物动词】缺乏,不足,没有; 【名词】缺乏,不足
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    lack of activation 缺乏激活
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    mice 老鼠【名词】(pl.) mouse
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    missing enzyme 缺失的酶
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    muscle 肌肉【名词】【解剖学】肌(肉);体力,膂力,力气; 【不及物动词】发挥膂力;用力挤着前进;muscle in 硬挤进;干涉,侵入;强夺
  • natriuretic peptide 利尿钠肽; 尿钠肽
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    normal blood pressure 正常血压
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    peptide 肽;缩氨酸
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    pressure 压力【名词】压,气压,压强,高压,加压
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    regulate 【及物动词】1.管制;控制;规定 2. 调节;调整 3.校准(钟表等);使规律化
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    setting 1. 设置; 设定; 安装 2. 环境;背景; 布置
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    sodium 钠【名词】
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    the body's sodium and water balance 体内的钠和水平衡
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    treated patient 治疗的患者
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    ultimately 【副词】 最终地 ; 根本地;首要地
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