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Heartburn Meds Linked to CKD


NBC Nightly News - February 8, 2016 约翰·霍普金斯大学研究发现抑酸剂影响肾功能。 Johns Hopkins study connects acid-reducing drugs to kidney issues.

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Lester Holt, Anchor, NBC Nightly News: Tonight, a new warning about some of the most popular prescription drugs in America treating heartburn and acid reflux. They're now also sold over the counter. While it's already known they're linked to a risk of fractures and infections, now a new study finds they can have another serious side effect. NBC's Anne Thompson has the details:
Announcer: Can't afford to let heartburn get in the way?
Anne Thompson, Reporter, NBC Nightly News: Stopping heartburn is big business...(MAN: Zero heartburn!)...Sold as Nexium (esomeprazole) [AZN], Prilosec (omeprazole) [P&G] and Prevacid (lansoprazole) [Takeda], more than 15 million Americans shelled out over $10 billion in 2013 for the prescription versions of these drugs called "proton pump inhibitors" (PPI). Now, a new study from Johns Hopkins says these acid-reducing drugs may increase the risk for chronic kidney disease (CKD) [by] 20-50%. Cleveland Clinic kidney specialist Dr. Sheru Kansal is treating Kim Henkel.
Dr. Sheru Kansal, Nephrologist, Cleveland Clinic: Kim had normal kidney function in March, and then bloodwork in August showed kidney function down to 30%.
AT: Kim was taking one of the over-the-counter versions. On a hunch, Dr. Kansal had Kim stop, and her kidneys improved.
Kim Henkel: I was lucky it was caught early, and that we can do something about it.
AT: For over-the-counter acid reducers, the FDA (Food and Drug Administration) recommends they be used for 14 days, and no more than three times a year. For the prescription versions, the package insert recommends for most conditions [that] the pills be taken for up to eight weeks.
Dr. Jonathan Aviv, Otolaryngologist, Mount Sinai Hospital: Pills are not the only answer. Food is the answer.
AT: Dr. Jonathan Aviv prescribes the drugs, but insists his patients also avoid acidic foods like berries, chocolate and anything with caffeine, for 28 days.
JA: You can change your diet and reduce acid production, and actually heal your own body by what you're eating.
AT: The makers of these drugs say they are safe and effective when used correctly. That and diet can keep stomach acid where it belongs. Anne Thompson, NBC News, New York.
LH: Hey NBC News fans! Thanks for checking out our YouTube channel. Subscribe by clicking on that button down here, and click on any of the videos over here to watch the latest interviews, show highlights and digital exclusives. Thanks for watching!

  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    acid 酸【名词】酸性,耐酸
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    acid production 产酸作用
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    acid reducer 抑酸剂
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    acid reflux 胃酸反流
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    acid-reducing drug 抑酸药
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    acidic 【形容词】酸的,酸性的;产生酸的
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    acidic food 酸性食物
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    administration 【名词】1. 管理,经营;行政 2. 行政机关,局[处、署];(A- 主美)政府; 3. 给与;施行; 4. 给药,(药的)服法; 5. 【军事】后方勤务; 6. 【法律】施行,执行
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    anchor 【名词】1. 锚;新闻主播 2. 桩; 支架; 依靠; 【不及物动词】1. 抛锚; 2. 停泊;固定; 【及物动词】1. 抛锚泊(船); 2. 把…固定住
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    Big Business 1.大企业;财团;大公司 2.大生意
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    bloodwork 血液检查
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    caffeine 咖啡因
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    chronic 慢性【形容词】1. 慢性的;长期的;积习成癖的。; 2. (英俚)剧烈的,(天气等)恶劣的。; chronically 【副词】慢性地,不断地。
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    chronic kidney disease 慢性肾病◆【略】CKD
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    Cleveland Clinic 克利夫兰诊所
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    clinic 诊所【名词】1. 临床讲授;临床实习课; 2. 诊所;门诊部; 3. 特殊病例分析;会诊
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    conditioning 调理
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    diet 饮食;节食
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    digital exclusive 数字化消息独家报道
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    disease 【名词】1. 病,疾病;【植物】病害 2. (精神等的)病态,弊病 3. (酒等的)变质;(食物等的)腐败
  • drug administration 药品监督管理; 给药; 服药
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    drugged 【及物动词】用药麻醉;使服药;使服毒品
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    effective 有效【形容词】1. 有效(力)的,灵验的;显眼的,(美国)生效的,被实施的;【军事】有战斗力的; 2. 【经济学】实质上的;有实价的; 3. 【军事】精锐的
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    esomeprazole 艾美拉唑 <抗溃疡病药>
  • Extracting Microarray Gene Expression Patterns and Identifying co-expressed Genes 提取微阵列基因表达模式和确认共表达基因◆【略】EPIG
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    finding 【名词】1.发现,发现物,调查的结果,研究结果; 2. 裁决,定罪 【动词原形】find
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    fracture 骨折【名词】1. 破裂,折断,断裂; 2. 裂痕,裂缝,裂面; 3. 【医学】挫伤,骨折; 4. 【矿物】断口;【地质学;地理学】断层; 【及物动词, 不及物动词】(使)破裂;(使)折断;(使)断裂
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    get in the way 阻碍
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    heal 治愈【及物动词】1. 医治,治愈(病伤等);使恢复健康; 2. 使恢复;使和解; 【不及物动词】(病)痊愈,恢复健康
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    heartburn 胃(心)灼热;胃痛
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    highlight 突出显示【及物动词】在…上投上强光;强调,使显著;【美剧】派给;当主角; 【名词】(画中受光最多的)明亮部份;(常 pl.)(演出等的)精彩场面,精彩节目;(报纸中等)特讯,要闻;要点
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    hospital 医院【名词】院,住院
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    hunch 【名词】1. 肉峰,隆肉; 2. 厚片,大块; 3. 堆; 4. (美口)预感,第六感觉
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    increase the risk 增加风险
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    infection 感染【名词】1. 传染,感染,侵染; 2. 传染病,染毒物; 3. 影响;感染
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    inhibitor 抑制剂【名词】抑制因子,缓蚀剂,阻垢剂
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    interview 【名词】1. 接见;面谈;面试 2. (记者的)访问;采访 3. 口头审查 【及物动词】接见;会见;(记者)访谈
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    kidney 【名词】1. 【解剖学】肾; 肾脏 2. (动物的)腰子(供食用); 3. 脾气,性格; 类别
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    kidney disease 肾脏疾病
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    kidney function 肾脏功能
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    kidney specialist 肾病专家
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    lansoprazole 兰索拉唑
  • mount 【及物动词】1. 安放; 设置; 启动 2.爬上; 登上 3.骑上; 【不及物动词】 1. 增加; 加剧;上升 2. 登; 骑; 【名词】 山峰; 底座; 装帧
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    nephrologist 肾病
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    new warning 新的警告
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    Nexium 耐适恩, 治疗消化性溃疡, 胃食道反流的药物
  • normal kidney 正常肾
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    normal kidney function 正常肾功能
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    omeprazole 奥美拉唑
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    otolaryngologist 耳鼻喉科学医生◆【略】ENT
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    over the counter 非处方
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    over-the-counter version 非处方的版本◆【略】OTC
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    package insert 药品说明书;包装说明书
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    packaging 【名词】包装;包装业
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    pill 丸【1名词】1. 丸,药丸; (the birth control pill/the pill) (女用口服)避孕丸; 2. 讨厌的东西[人];苦事; 3. (俚语)炮弹,子弹;球;(pl.)(英俚)撞球战,弹子战; 4. (美俚)香烟;切去两端的雪茄烟;(鸦片)烟泡; 5. 投票用小球; 6. 【农业】粒肥;【及物动词】1. 把…作成丸药;给…吃丸药; 2. (俚语)投票反对;排斥;不录取;开除;【及物动词】(古语)抢劫,掠夺
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    prescribe 【及物动词】1. 处方;嘱咐(疗法) 2. 命令;指示;规定;限制 3. 【法律】使(过限期而)失效 【不及物动词】1. 开药方,给医嘱 2. 命令;指示;规定 3.【法律】(长期占有)要求权利;(因过期限而)失效
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    prescription 【名词】1. 处方;处方的药;解救方法 2. 命令;规定;法规 3.【法律】(由于长期使用等而)获得权利 【形容词】按处方配制的◆【対】over-the-counter (OTC)
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    prescription drug 处方药
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    prescription version 处方类药物
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    Prevacid 兰索拉唑
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    Prilosec 奥美拉唑(非处方质子泵抑制剂)
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    reducer 减速器
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    reflux 反流【名词】1. 回流,反流,倒流,逆流;退潮; 2. 【化学】回流加热
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    risk of fractures and infections 骨折和感染的危险
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    safe and effective 安全有效的
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    safe and effective when used correctly 当正确使用时是安全有效的
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    serious side effect 严重的副作用
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    side effect 副作用; 意外情况
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    sold over-the-counter 在场外市场出售,非处方出售◆【略】OTC
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    some of the most popular prescription drugs in America 在美国一些最常用的处方药
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    specialist 专家◆【略】GP◆【参考】general practitioner
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    stomach 胃,腹部,胃口,食欲,嗜好,欲望
  • Sound e31a43d441998f862b764d17930467a5a23de45c433219259bed5eb42e3a7615
    stomach acid 胃酸
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    used correctly 正确地使用
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    warning 【名词】1. 警告,警报;警戒;训诫 2. 预告,通知 3. 号召 4. 殷鉴;前兆
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