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Found: 238
Immunity & Ageing
  • Changes in peripheral immune cell numbers and functions in octogenarian walkers – an acute exercise study

    Immunity & Ageing

    Kornelis S. M. van der Geest; Qi Wang; Thijs M. H. Eijsvogels; Hans J. P. Koenen; Irma Joosten; Elisabeth Brouwer; Maria T. E. Hopman; Joannes F. M. Jacobs; Annemieke M. H. Boots

    Background Age-related changes of the immune system, termed immunosenescence, may underlie the increased risk of infections and morbidity in the elderly. Little is known about the effects of acute exercise on peripheral immune parameters in octogenarians. Therefore, we investigated acute exerci...
  • Expression of cellular protective proteins SIRT1, HSP70 and SOD2 correlates with age and is significantly higher in NK cells of the oldest seniors

    Immunity & Ageing

    Lucyna Kaszubowska; Jerzy Foerster; Jan Jacek Kaczor; Daria Schetz; Tomasz Jerzy Ślebioda; Zbigniew Kmieć

    Background NK cells are key effector lymphocytes of innate immunity provided with constitutive cytolytic activity, however, their role in human ageing is not entirely understood. The study aimed to analyze the expression of proteins involved in cellular stress response sirtuin 1 (SIRT1), heat s...
  • Lifewide profile of cytokine production by innate and adaptive immune cells from Brazilian individuals

    Immunity & Ageing

    Gabriela Silveira-Nunes; Elaine Speziali; Andréa Teixeira-Carvalho; Danielle M. Vitelli-Avelar; Renato Sathler-Avelar; Taciana Figueiredo-Soares; Maria Luiza Silva; Vanessa Peruhype-Magalhães; Daniel Gonçalves Chaves; Gustavo Eustáquio Brito-Melo; Glenda Meira Cardoso; Eric Bassetti Soares; Silvana Maria Elói-Santos; Rosângela Teixeira; Dulciene Magalhães Queiroz; Rodrigo Corrêa-Oliveira; Ana Maria Caetano Faria; Olindo Assis Martins-Filho

    Background Immunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytokine global profiles produced by distinct populations of leukocytes from hea...
  • A pilot observational study on magnesium and calcium imbalance in elderly patients with acute aortic dissection

    Immunity & Ageing

    E. Vianello; E. Dozio; A. Barassi; G. Sammarco; L. Tacchini; M. M. Marrocco-Trischitta; S. Trimarchi; M. M. Corsi Romanelli

    Background Magnesium (Mg) and calcium (Ca) are the principal essential elements involved in endothelial cell homeostasis. Extracellular changes in the levels of either alter endothelial contraction and dilatation. Consequently Mg and Ca imbalance is associated with a high risk of endothelial dy...
  • Frailty has a stronger association with inflammation than age in older veterans

    Immunity & Ageing

    P. Van Epps; D. Oswald; P. A. Higgins; T. R. Hornick; H. Aung; R. E. Banks; B. M. Wilson; C. Burant; S. Graventstein; D. H. Canaday

    Background Upregulation of pro-inflammatory cytokines has not only been associated with increased morbidity and mortality in older adults but also has been linked to frailty. In the current study we aimed to compare the relative relationship of age and frailty on inflammation and thrombosis in ...
  • Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults

    Immunity & Ageing

    Marco Grasse; Andreas Meryk; Michael Schirmer; Beatrix Grubeck-Loebenstein; Birgit Weinberger

    We have recently demonstrated that single shot vaccinations against tetanus and diphtheria do not lead to long-lasting immunity against diphtheria in elderly persons despite administration at 5 year intervals. In the present study we have immunized a group of young adults against tetanus and dip...
  • The inflammatory protein Pentraxin 3 in cardiovascular disease

    Immunity & Ageing

    Francesco Fornai; Albino Carrizzo; Maurizio Forte; Mariateresa Ambrosio; Antonio Damato; Michela Ferrucci; Francesca Biagioni; Carla Busceti; Annibale A. Puca; Carmine Vecchione

    The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate immunity and inflammation. Recent evidence indicates that PTX3 exerts an important rol...
  • Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors

    Immunity & Ageing

    Yun Lin; Jiewan Kim; E. Jeffrey Metter; Huy Nguyen; Thai Truong; Ana Lustig; Luigi Ferrucci; Nan-ping Weng

    Background Alterations in the number and composition of lymphocytes and their subsets in blood are considered a hallmark of immune system aging. However, it is unknown whether the rates of change of lymphocytes are stable or change with age, or whether the inter-individual variations of lymphoc...
  • Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis

    Immunity & Ageing

    A. Trovato; R. Siracusa; R. Di Paola; M. Scuto; M. L. Ontario; Ornella Bua; Paola Di Mauro; M. A. Toscano; C. C. T. Petralia; L. Maiolino; A. Serra; S. Cuzzocrea; Vittorio Calabrese

    Background There has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional in delaying the onset of age-associated neurodegenerative diseases. Mushrooms have long been used in traditional medicine for thousands of years, being now incre...
  • Elastic band resistance training influences transforming growth factor-ß receptor I mRNA expression in peripheral mononuclear cells of institutionalised older adults: the Vienna Active Ageing Study (VAAS)

    Immunity & Ageing

    Barbara Schober-Halper; Marlene Hofmann; Stefan Oesen; Bernhard Franzke; Thomas Wolf; Eva-Maria Strasser; Norbert Bachl; Michael Quittan; Karl-Heinz Wagner; Barbara Wessner

    Background Ageing, inactivity and obesity are associated with chronic low-grade inflammation contributing to a variety of lifestyle-related diseases. Transforming growth factor-β (TGF-β) is a multimodal protein with various cellular functions ranging from tissue remodelling to the regulation of...
  • Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

    Immunity & Ageing

    Monika Puzianowska-Kuźnicka; Magdalena Owczarz; Katarzyna Wieczorowska-Tobis; Pawel Nadrowski; Jerzy Chudek; Przemyslaw Slusarczyk; Anna Skalska; Marta Jonas; Edward Franek; Malgorzata Mossakowska

    Background In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and older, we investigated whether the serum levels of two proinflammatory factor...
  • Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes

    Immunity & Ageing

    Emanuela Corsini; Valentina Galbiati; Angela Papale; Elena Kummer; Antonella Pinto; Melania M. Serafini; Antonio Guaita; Roberto Spezzano; Donatella Caruso; Marina Marinovich; Marco Racchi

    Background Over the past fifteen years, we have demonstrated that cortisol and dehydroepiandrosterone (DHEA) have opposite effects on the regulation of protein kinase C (PKC) activity in the context of the immune system. The anti-glucocorticoid effect of DHEA is also related to the regulation o...
  • Nutrigerontology: a key for achieving successful ageing and longevity

    Immunity & Ageing

    Anna Aiello; Giulia Accardi; Giuseppina Candore; Giuseppe Carruba; Sergio Davinelli; Giuseppe Passarino; Giovanni Scapagnini; Sonya Vasto; Calogero Caruso

    During the last two centuries the average lifespan has increased at a rate of approximately 3 months/year in both sexes, hence oldest old people are becoming the population with the fastest growth in Western World. Although the average life expectancy is increasing dramatically, the healthy life...
  • Effects of thermal water inhalation in chronic upper respiratory tract infections in elderly and young patients

    Immunity & Ageing

    Thea Magrone; Mauro Galantino; Nunzio Di Bitonto; Luisella Borraccino; Gerardo Chiaromonte; Emilio Jirillo

    Background Chronic upper respiratory tract infections (cURTI) are very frequent illnesses which occur at any age of life. In elderly, cURTI are complicated by immunosenescence, with involvement of lung immune responsiveness. Results In the present study, 51 elderly (age range: 66-86) and 51 y...
  • The insulin receptor substrate Chico regulates antibacterial immune function in Drosophila

    Immunity & Ageing

    Sarah McCormack; Shruti Yadav; Upasana Shokal; Eric Kenney; Dustin Cooper; Ioannis Eleftherianos

    Background Molecular and genetic studies in model organisms have recently revealed a dynamic interplay between immunity and ageing mechanisms. In the fruit fly Drosophila melanogaster, inhibition of the insulin/insulin-like growth factor signaling pathway prolongs lifespan, and mutations in the...
  • Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges

    Immunity & Ageing

    Sergio Davinelli; Michael Maes; Graziamaria Corbi; Armando Zarrelli; Donald Craig Willcox; Giovanni Scapagnini

    AbstractAn extensive literature describes the positive impact of dietary phytochemicals on overall health and longevity. Dietary phytochemicals include a large group of non-nutrients compounds from a wide range of plant-derived foods and chemical classes. Over the last decade, remarkable progress...
  • β-glucans: ex vivo inflammatory and oxidative stress results after pasta intake

    Immunity & Ageing

    Annalisa Barera; Silvio Buscemi; Roberto Monastero; Calogero Caruso; Rosalia Caldarella; Marcello Ciaccio; Sonya Vasto

    It is well known that Mediterranean Diet can positively influence the health of each individual, in particular it is know that fibers have an important role. However, in Mediterranean cities most people do not have a close adherence to Mediterranean diet. Thus, in our study, we considered fibers...
  • Nutrition, aging and cancer: lessons from dietary intervention studies

    Immunity & Ageing

    Giuseppe Carruba; Letizia Cocciadiferro; Antonietta Di Cristina; Orazia M. Granata; Cecilia Dolcemascolo; Ildegarda Campisi; Maurizio Zarcone; Maria Cinquegrani; Adele Traina

    AbstractThere is convincing epidemiological and clinical evidence that, independent of aging, lifestyle and, notably, nutrition are associated with development or progression of major human cancers, including breast, prostate, colorectal tumors, and an increasingly large collection of diet-relate...
  • Nutraceutical effects of table green olives: a pilot study with Nocellara del Belice olives

    Immunity & Ageing

    Giulia Accardi; Anna Aiello; Valeria Gargano; Caterina Maria Gambino; Santo Caracappa; Sandra Marineo; Gesualdo Vesco; Ciriaco Carru; Angelo Zinellu; Maurizio Zarcone; Calogero Caruso; Giuseppina Candore

    The aim of this study was to analyse the nutraceutical properties of table green olives Nocellara del Belice, a traditional Mediterranean food. The Mediterranean Diet has as key elements olives and extra virgin olive oil, common to all Mediterranean countries. Olive oil is the main source of fat...
  • Human longevity: Genetics or Lifestyle? It takes two to tango

    Immunity & Ageing

    Giuseppe Passarino; Francesco De Rango; Alberto Montesanto

    AbstractHealthy aging and longevity in humans are modulated by a lucky combination of genetic and non-genetic factors. Family studies demonstrated that about 25 % of the variation in human longevity is due to genetic factors. The search for genetic and molecular basis of aging has led to the iden...
  • HCV monoinfection and HIV/HCV coinfection enhance T-cell immune senescence in injecting drug users early during infection

    Immunity & Ageing

    Bart P. X. Grady; Nening M. Nanlohy; Debbie van Baarle

    Injecting drug users (IDU) are at premature risk of developing multimorbidity and mortality from causes commonly observed in the elderly. Ageing of the immune system (immune-senescence) can lead to premature morbidity and mortality and can be accelerated by chronic viral infections. Here we inve...
  • Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians

    Immunity & Ageing

    Jungwon Han; So-Hyun Park; Dong-Jo Kim; Hyori Kim; Yoon-Ho Choi; Jong-Hyuk Lee; Sang Chul Park; Junho Chung

    Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians. Results We used a phage-displayed combinatorial peptide library to screen for peptides (YSATLR...
  • Acute phase of aortic dissection: a pilot study on CD40L, MPO, and MMP-1, -2, 9 and TIMP-1 circulating levels in elderly patients

    Immunity & Ageing

    E. Vianello; E. Dozio; R. Rigolini; M. M. Marrocco-Trischitta; L. Tacchini; S. Trimarchi; M. M. Corsi Romanelli

    Acute aortic dissection (AAD) is an event which may be rapidly fatal without early diagnosis and treatment. Aging is one of the main risk factors that could leading to AAD. To date, no specific biomarkers are available to increase the speed of diagnosis. CD40 ligand (CD40L), myeloperoxidase (MPO...
  • TLR-6 SNP P249S is associated with healthy aging in nonsmoking Eastern European Caucasians - A cohort study

    Immunity & Ageing

    Lutz Hamann; Jasmin Bustami; Leonid Iakoubov; Malgorzata Szwed; Malgorzata Mossakowska; Ralf R. Schumann; Monika Puzianowska-Kuznicka

    To investigate mechanisms that determine healthy aging is of major interest in the modern world marked by longer life expectancies. In addition to lifestyle and environmental factors genetic factors also play an important role in aging phenotypes. The aged immune system is characterized by a chr...
  • Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence

    Immunity & Ageing

    Agnieszka Przemska-Kosicka; Caroline E. Childs; Sumia Enani; Catherine Maidens; Honglin Dong; Iman Bin Dayel; Kieran Tuohy; Susan Todd; Margot A. Gosney; Parveen Yaqoob

    Ageing increases risk of respiratory infections and impairs the response to influenza vaccination. Pre- and probiotics offer an opportunity to modulate anti-viral defenses and the response to vaccination via alteration of the gut microbiota. This study investigated the effect of a novel probioti...
  • Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study

    Immunity & Ageing

    Shu-Chun Chuang; Heiner Boeing; Stein Emil Vollset; Øivind Midttun; Per Magne Ueland; Bas Bueno-de-Mesquita; Martin Lajous; Guy Fagherazzi; Marie-Christine Boutron-Ruault; Rudolf Kaaks; Tilman Küehn; Tobias Pischon; Dagmar Drogan; Anne Tjønneland; Kim Overvad; J Ramón Quirós; Antonio Agudo; Esther Molina-Montes; Miren Dorronsoro; José María Huerta; Aurelio Barricarte; Kay-Tee Khaw; Nicholas J. Wareham; Ruth C. Travis; Antonia Trichopoulou; Pagona Lagiou; Dimitrios Trichopoulos; Giovanna Masala; Claudia Agnoli; Rosario Tumino; Amalia Mattiello; Petra H Peeters; Elisabete Weiderpass; Richard Palmqvist; Ingrid Ljuslinder; Marc Gunter; Yunxia Lu; Amanda J. Cross; Elio Riboli; Paolo Vineis; Krasimira Aleksandrova

    Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (...
  • Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration

    Immunity & Ageing

    Judith Lechner; Mei Chen; Ruth E. Hogg; Levente Toth; Giuliana Silvestri; Usha Chakravarthy; Heping Xu

    The aim of this study was to investigate the plasma levels of complement C3a, C4a, and C5a in different types of neovascular age-related macular degeneration (nAMD) and whether the levels were related to patients’ responsiveness to anti-VEGF therapy. Results Ninety-six nAMD patients (including ...
  • Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy

    Immunity & Ageing

    Manuela Zlamy; Giovanni Almanzar; Walther Parson; Christian Schmidt; Johannes Leierer; Birgit Weinberger; Verena Jeller; Karin Unsinn; Matthias Eyrich; Reinhard Würzner; Martina Prelog

    Homeostatic mechanisms to maintain the T cell compartment diversity indicate an ongoing process of thymic activity and peripheral T cell renewal during human life. These processes are expected to be accelerated after childhood thymectomy and by the influence of cytomegalovirus (CMV) inducing a p...
  • Pneumococcal colonization in older adults

    Immunity & Ageing

    Susanna Esposito; Daniela Mari; Luigi Bergamaschini; Annalisa Orenti; Leonardo Terranova; Luca Ruggiero; Valentina Ierardi; Monia Gambino; Francesco Della Croce; Nicola Principi

    Little is known about pneumococcal carrier states in older adults. The main aim of this study was to evaluate pneumococcal colonization patterns among older adults in two centres in Milan, Italy, before the widespread use of the 13-valent pneumococcal vaccine (PCV13) in this age group, to invest...
  • Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years

    Immunity & Ageing

    Helen M. Parry; Jianmin Zuo; Guido Frumento; Nikhil Mirajkar; Charlotte Inman; Emma Edwards; Mike Griffiths; Guy Pratt; Paul Moss

    Cytomegalovirus (CMV) is a highly prevalent herpesvirus, which maintains lifelong latency and places a significant burden on host immunity. Infection is associated with increased rates of vascular disease and overall mortality in the elderly and there is an urgent need for improved understanding...