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World Allergy Organization Journal
  • Climate change, allergy and asthma, and the role of tropical forests

    World Allergy Organization Journal

    Gennaro D’Amato; Carolina Vitale; Nelson Rosario; Herberto Josè Chong Neto; Deborah Carla Chong-Silva; Francisco Mendonça; Josè Perini; Loraine Landgraf; Dirceu Solé; Mario Sánchez-Borges; Ignacio Ansotegui; Maria D’Amato

    Background Tropical forests cover less than 10 per cent of all land area (1.8 × 107 km2) and over half of the tropical-forest area (1.1 × 107 Km2) is represented by humid tropical forests (also called tropical rainforests). The Amazon basin contains the largest rainforest on Earth, almost 5.8 m...
  • Allergic diseases and asthma in pregnancy, a secondary publication

    World Allergy Organization Journal

    Isabella Pali-Schöll; Jennifer Namazy; Erika Jensen-Jarolim

    Every fifth pregnant woman is affected by allergies, especially rhinitis and asthma. Allergic symptoms existing before pregnancy may be either attenuated, or equally often promoted through pregnancy. Optimal allergy and asthma diagnosis and management during pregnancy is vital to ensure the welf...
  • The impact on quality of life on families of children on an elimination diet for Non-immunoglobulin E mediated gastrointestinal food allergies

    World Allergy Organization Journal

    Rosan Meyer; Heather Godwin; Robert Dziubak; Julie A. Panepinto; Ru-Xin M. Foong; Mandy Bryon; Adriana Chebar Lozinsky; Kate Reeve; Neil Shah

    Background The impact on health related quality of life (HRQL) has been well studied in children with Immunoglobulin E (IgE)-mediated food allergy. However limited data exists on related quality of life (QOL) of families who have a child suffering from food protein induced non-IgE mediated gast...
  • Effect of adjuvanted and standard sublingual immunotherapy on respiratory function in pure rhinitis due to house dust mite over a 5-year period

    World Allergy Organization Journal

    Maurizio Marogna; Alessandro Massolo; Giovanni Passalacqua

    Background Allergen-specific immunotherapy (AIT) still remains the only causal treatment for IgE mediated respiratory diseases (rhinitis/asthma) In addition to the observed clinical decrease in symptoms, AIT can provide a long-lasting and preventive effect. In particular it can modify the progr...
  • An unusual cause of food-induced anaphylaxis in mothers

    World Allergy Organization Journal

    J. Y. Soh; W. C. Chiang; C. H. Huang; C. K. Woo; I. Ibrahim; K. Heng; A. Pramanick; B. W. Lee

    Background Galacto-oligosaccharides (GOS) are prebiotics added to commercial milk formula of infants and mothers. In recent years, cases of allergy related to GOS in atopic children have been reported in the South East Asian region. Case presentations We describe a series of pregnant (n = 4) ...
  • Anaphylaxis in a 4-year-old male caused by contact with grasses: a case report

    World Allergy Organization Journal

    Germán Darío Ramón; Victor H. Croce; Iván Chérrez Ojeda

    Background Acute urticaria is the presence of urticaria for <6 weeks, and it is the most common type of urticaria in children. Sometimes, it may be associated with anaphylaxis, a life-threatening condition. Urticaria must be differentiated from anaphylaxis because the latter may require emer...
  • Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel

    World Allergy Organization Journal

    Alkis Togias; Susan F. Cooper; Maria L. Acebal; Amal Assa’ad; James R. Baker; Lisa A. Beck; Julie Block; Carol Byrd-Bredbenner; Edmond S. Chan; Lawrence F. Eichenfield; David M. Fleischer; George J. Fuchs; Glenn T. Furuta; Matthew J. Greenhawt; Ruchi S. Gupta; Michele Habich; Stacie M. Jones; Kari Keaton; Antonella Muraro; Marshall Plaut; Lanny J. Rosenwasser; Daniel Rotrosen; Hugh A. Sampson; Lynda C. Schneider; Scott H. Sicherer; Robert Sidbury; Jonathan Spergel; David R. Stukus; Carina Venter; Joshua A. Boyce

    Background Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and ...
  • Is allergic sensitization relevant in severe asthma? Which allergens may be culprit?

    World Allergy Organization Journal

    Carlo Lombardi; Eleonora Savi; Erminia Ridolo; Giovanni Passalacqua; Giorgio Walter Canonica

    Severe asthma is a major health concern. The allergic (IgE-mediated) form of asthma is well known from a pathogenic viewpoint. We searched the available literature to identify which allergens are most frequently associated with severe, refractory or life threatening asthma. According to the resu...
  • Asthma heterogeneity and severity

    World Allergy Organization Journal

    Tara F. Carr; Eugene Bleecker

    Asthma is a common, chronic inflammatory airways disease characterized by a clinical syndrome of bronchial hyperresponsiveness, inflammation, and reversible airflow obstruction. Individuals with asthma can vary widely in clinical presentation, severity, and pathobiology. The incident factors, pa...
  • Therapeutic interventions in severe asthma

    World Allergy Organization Journal

    Giorgio Walter Canonica; Gianenrico Senna; Patrick D. Mitchell; Paul M. O’Byrne; Giovanni Passalacqua; Gilda Varricchi

    The present paper addresses severe asthma which is limited to 5-10% of the overall population of asthmatics. However, it accounts for 50% or more of socials costs of the disease, as it is responsible for hospitalizations and Emergency Department accesses as well as expensive treatments. The rece...
  • Omalizumab for chronic urticaria in Latin America

    World Allergy Organization Journal

    Paul Wilches; Paola Wilches; Juan Carlos Calderon; Annia Cherrez; Ivan Cherrez Ojeda

    Background Chronic urticaria (CU) is defined as the spontaneous appearance of wheals, with or without angioedema, persisting for ≥6 weeks. Chronic Spontaneous Urticaria (CSU) is a type of CU which affects 0.5-1 % of the global population, but it represents a high burden to patients. In recent y...
  • Cow’s milk allergy: towards an update of DRACMA guidelines

    World Allergy Organization Journal

    Alessandro Fiocchi; Lamia Dahda; Christophe Dupont; Cristina Campoy; Vincenzo Fierro; Antonio Nieto

    Background In 2010, the diagnosis and treatment of IgE-mediated CMA were systematized in a GRADE guideline. Objectives & methods After 6 years, the state of the knowledge in diagnosis and treatment of CMA has largely evolved. We summarize here the main advances, and exemplify indicating s...
  • Manifesto on small airway involvement and management in asthma and chronic obstructive pulmonary disease: an Interasma (Global Asthma Association - GAA) and World Allergy Organization (WAO) document endorsed by Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Allergy and Asthma European Network (GA2LEN)

    World Allergy Organization Journal

    F. Braido; N. Scichilone; F. Lavorini; O. S. Usmani; L. Dubuske; L. P. Boulet; R. Mosges; C. Nunes; M. Sanchez-Borges; I. J. Ansotegui; M. Ebisawa; F. Levi-Schaffer; L. J. Rosenwasser; J. Bousquet; T. Zuberbier; G. Walter Canonica

    Evidence that enables us to identify, assess, and access the small airways in asthma and chronic obstructive pulmonary disease (COPD) has led INTERASMA (Global Asthma Association) and WAO to take a position on the role of the small airways in these diseases. Starting from an extensive literature...
  • Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement

    World Allergy Organization Journal

    Marek L. Kowalski; Ignacio Ansotegui; Werner Aberer; Mona Al-Ahmad; Mubeccel Akdis; Barbara K. Ballmer-Weber; Kirsten Beyer; Miguel Blanca; Simon Brown; Chaweewan Bunnag; Arnaldo Capriles Hulett; Mariana Castells; Hiok Hee Chng; Frederic De Blay; Motohiro Ebisawa; Stanley Fineman; David B. K. Golden; Tari Haahtela; Michael Kaliner; Connie Katelaris; Bee Wah Lee; Joanna Makowska; Ulrich Muller; Joaquim Mullol; John Oppenheimer; Hae-Sim Park; James Parkerson; Giovanni Passalacqua; Ruby Pawankar; Harald Renz; Franziska Rueff; Mario Sanchez-Borges; Joaquin Sastre; Glenis Scadding; Scott Sicherer; Pongsakorn Tantilipikorn; James Tracy; Vera van Kempen; Barbara Bohle; G Walter Canonica; Luis Caraballo; Maximiliano Gomez; Komei Ito; Erika Jensen-Jarolim; Mark Larche; Giovanni Melioli; Lars K. Poulsen; Rudolf Valenta; Torsten Zuberbier

    One of the major concerns in the practice of allergy is related to the safety of procedures for the diagnosis and treatment of allergic disease. Management (diagnosis and treatment) of hypersensitivity disorders involves often intentional exposure to potentially allergenic substances (during ski...
  • Proceedings of the 2015 WAO Symposium on Food Allergy and the Microbiome

    World Allergy Organization Journal

    Raúl Lázaro Castro Almarales; Mary Carmen Reyes Zamora; Beatriz Tamargo; Damaris Torralba Averoff; Raysa Cruz; Yunia Oliva Diaz; Mirta Alvarez Castello; Alexander Ciria; Alexis Labrada; Maytee Mateo; Maytee Mateo; Damaris Torralba Averoff; Raysa Cruz; Yunia Oliva Diaz; Mirta Alvarez Castello; Alexander Ciria; Mary Carmen Reyes Zamora; Beatriz Tamargo; Alexis Labrada; Omar Herrera; Maytee Mateo; Raysa Cruz; Mirta Alvarez Castello; Alexander Ciria; Raúl Lázaro Castro Almarales; Mary Carmen Reyes Zamora; Alexis Labrada; José Severino Rodríguez Canosa; Raysa Cruz; Maytee Mateo; Mirta Alvarez Castello; Alexander Ciria; Raúl Lázaro Castro Almarales; Mary Carmen Reyes Zamora; Alexis Labrada; Mirta Alvarez Castello; Raúl Lázaro Castro Almarales; Alexis Labrada; Yamilet Ibizate Novales; Ilonka Estruch Fajardo; Alexis Labrada; Maytee Mateo; Armando Ginard; Bruce Lanser; Anna Faino; Erwin Gelfand; Pia Hauk; Silvia Venero Fernández; Julia Urbina; Mirta Alvarez Castello; Raúl Lázaro Castro Almarales; Ramón Suárez Medina; Hermes Fundora Hernández; John Britton; Andrew William Fogarty; Nabarun Ghosh; Clinton Ross Bell; Chandini Revanna; Constantine Saadeh; Jeff Bennert; Danius Bouyi; Mitsy Veloz; Nelofar Sherali; Magna Coelho; Nabarun Ghosh; Jeff Bennert; Danius Bouyi; Constantine Saadeh; Clinton Ross Bell; Mitsy Veloz; Chandini Revanna; Nelofar Sherali; Joseph J. Dolence; Takao Kobayashi; Koji Iijima; Hirohito Kita; Hirohito Kita; Ashli Moore; James Krempski; Roberta Aina; Riccardo Asero; Sabine Pfeifer; Pawel Dubiela; Merima Bublin; Christian Radauer; Piotr Humeniuk; Karin Hoffmann-Sommergruber; Frank Eidelman; Ves Dimov; Charl Khalil; Ves Dimov; Frank Eidelman; Charl Khalil; Alice E. W. Hoyt; Peter Heymann; Alexander Schuyler; Scott Commins; Thomas Platts-Mills; Alexander Schuyler; Patrice Kruszewski; John Russo; Lisa Workman; Thomas Platts-Mills; Elizabeth Erwin; Anubha Tripathi; Gabriela Yvette Castellanos; Elizabeth Mendieta; Martín Becerril-Angeles

    Table of contents A1 Characterization of the immunoallergic profile towards the proteins of the wheat flour in Cuban population Raúl Lázaro Castro Almarales, Mary Carmen Reyes Zamora, Beatriz Tamargo, Damaris Torralba Averoff, Raysa Cruz, Yunia Oliva Diaz, Mirta Alvarez Castello, Alexander Ciria...
  • Heated egg yolk challenge predicts the natural course of hen’s egg allergy: a retrospective study

    World Allergy Organization Journal

    Yu Okada; Noriyuki Yanagida; Sakura Sato; Motohiro Ebisawa

    Background Children do not always outgrow hen’s egg allergies in early childhood. Because egg yolks are less allergenic than egg whites, we performed an oral food challenge with heated egg yolk slightly contaminated with egg white (EYSEW OFC) in infants allergic to hen’s egg. We hypothesized th...
  • International Consensus (ICON): allergic reactions to vaccines

    World Allergy Organization Journal

    Stephen C. Dreskin; Neal A. Halsey; John M. Kelso; Robert A. Wood; Donna S. Hummell; Kathryn M. Edwards; Jean-Christoph Caubet; Renata J. M. Engler; Michael S. Gold; Claude Ponvert; Pascal Demoly; Mario Sanchez-Borges; Antonella Muraro; James T. Li; Menachem Rottem; Lanny J. Rosenwasser

    Background Routine immunization, one of the most effective public health interventions, has effectively reduced death and morbidity due to a variety of infectious diseases. However, allergic reactions to vaccines occur very rarely and can be life threatening. Given the large numbers of vaccines...
  • Tiotropium in asthma: what is the evidence and how does it fit in?

    World Allergy Organization Journal

    David M. G. Halpin

    Despite current therapeutic approaches asthma remains uncontrolled in a significant proportion of patients. Short-acting anticholinergic bronchodilators have a very long history of use in asthma, and recent data confirms the importance of acetylcholine as both a bronchoconstrictor and as a regul...
  • Exposure to positively- and negatively-charged plasma cluster ions impairs IgE-binding capacity of indoor cat and fungal allergens

    World Allergy Organization Journal

    Kazuo Nishikawa; Takashi Fujimura; Yasuhiro Ota; Takuya Abe; Kareem Gamal ElRamlawy; Miyako Nakano; Tomoaki Takado; Akira Uenishi; Hidechika Kawazoe; Yoshinori Sekoguchi; Akihiko Tanaka; Kazuhisa Ono; Seiji Kawamoto

    Background Environmental control to reduce the amount of allergens in a living place is thought to be important to avoid sensitization to airborne allergens. However, efficacy of environmental control on inactivation of airborne allergens is not fully investigated. We have previously reported t...
  • Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics

    World Allergy Organization Journal

    Giuseppe di Mauro; Roberto Bernardini; Salvatore Barberi; Annalisa Capuano; Antonio Correra; Gian Luigi de’ Angelis; Iride Dello Iacono; Maurizio de Martino; Daniele Ghiglioni; Dora Di Mauro; Marcello Giovannini; Massimo Landi; Gian Luigi Marseglia; Alberto Martelli; Vito Leonardo Miniello; Diego Peroni; Lucilla Ricottini Maria Giuseppa Sullo; Luigi Terracciano; Cristina Vascone; Elvira Verduci; Maria Carmen Verga; Elena Chiappini

    Background Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades. Several interventions, functional foods, pro- and prebiotics, vitamins are proposed for the prevention of allergies and they can’t be uncritically adopted. Objective This Consensu...
  • The use of inhaled corticosteroids in pediatric asthma: update

    World Allergy Organization Journal

    Elham Hossny; Nelson Rosario; Bee Wah Lee; Meenu Singh; Dalia El-Ghoneimy; Jian Yi SOH; Peter Le Souef

    Despite the availability of several formulations of inhaled corticosteroids (ICS) and delivery devices for treatment of childhood asthma and despite the development of evidence-based guidelines, childhood asthma control remains suboptimal. Improving uptake of asthma management plans, both by fam...
  • Dissemination of definitions and concepts of allergic and hypersensitivity conditions

    World Allergy Organization Journal

    Luciana Kase Tanno; Moises A. Calderon; Helen E. Smith; Mario Sanchez-Borges; Aziz Sheikh; Pascal Demoly

    Background Allergy and hypersensitivity can affect people of any age and manifest with problems in a range of organ systems. Moreover, they can have a significant impact on the quality of life of patients and their families. Although once rare, there is presently an epidemic of allergic disorde...
  • Assessing worldwide research activity on probiotics in pediatrics using Scopus database: 1994–2014

    World Allergy Organization Journal

    Waleed M. Sweileh; Naser Y. Shraim; Samah W. Al-Jabi; Ansam F. Sawalha; Belal Rahhal; Rasha A. Khayyat; Sa’ed H. Zyoud

    Background A wide variety of probiotic products has been introduced into the market in the past decade. Research trends and activity on probiotics help understand how these products were evolved and their potential future role in medicine. The objective of this study was to assess the research ...
  • Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models

    World Allergy Organization Journal

    Anne C. A. Mudde; Willem S. Lexmond; Richard S. Blumberg; Samuel Nurko; Edda Fiebiger

    Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus and commonly classified as a Th2-type allergy. Major advances in our understanding of the EoE pathophysiology have recently been made, but clinicians struggle with highly unpredictable therapy responses indicative ...
  • Particularities of allergy in the Tropics

    World Allergy Organization Journal

    Luis Caraballo; Josefina Zakzuk; Bee Wah Lee; Nathalie Acevedo; Jian Yi Soh; Mario Sánchez-Borges; Elham Hossny; Elizabeth García; Nelson Rosario; Ignacio Ansotegui; Leonardo Puerta; Jorge Sánchez; Victoria Cardona

    Allergic diseases are distributed worldwide and their risk factors and triggers vary according to geographical and socioeconomic conditions. Allergies are frequent in the Tropics but aspects of their prevalence, natural history, risk factors, sensitizers and triggers are not well defined and som...
  • Eosinophilic bioactivities in severe asthma

    World Allergy Organization Journal

    Tara F. Carr; Sergejs Berdnikovs; Hans-Uwe Simon; Bruce S. Bochner; Lanny J. Rosenwasser

    Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through the production and release of diverse chem...
  • Retrospective cohort analysis of healthcare claims in the United States characterising asthma exacerbations in paediatric patients

    World Allergy Organization Journal

    Robert Y. Suruki; Nada Boudiaf; Hector G. Ortega

    Background Asthma is the most common chronic disease in childhood and places a significant burden on public and private health systems. This retrospective cohort analysis utilised administrative healthcare claims data (US Clinformatics™ Multiplan database; compliant with the US Department of He...
  • World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Vitamin D

    World Allergy Organization Journal

    Juan José Yepes-Nuñez; Alessandro Fiocchi; Ruby Pawankar; Carlos A. Cuello-Garcia; Yuan Zhang; Gian Paolo Morgano; Kangmo Ahn; Suleiman Al-Hammadi; Arnav Agarwal; Shreyas Gandhi; Kirsten Beyer; Wesley Burks; Giorgio W. Canonica; Motohiro Ebisawa; Rose Kamenwa; Bee Wah Lee; Haiqi Li; Susan Prescott; John J. Riva; Lanny Rosenwasser; Hugh Sampson; Michael Spigler; Luigi Terracciano; Andrea Vereda; Susan Waserman; Holger J. Schünemann; Jan L. Brożek

    Background The prevalence of allergic diseases is approximately 10 % in infants whose parents and siblings do not have allergic diseases and 20-30 % in those with an allergic first-degree relative. Vitamin D is involved in the regulation of the immune system and it may play a role in the develo...
  • Insights, attitudes, and perceptions about asthma and its treatment: a multinational survey of patients from Europe and Canada

    World Allergy Organization Journal

    Joaquin Sastre; Leonardo M. Fabbri; David Price; Hans Ulrich Wahn; Jean Bousquet; James E. Fish; Kevin Murphy; Malcolm R. Sears

    Background Asthma surveys completed within the past 10 years in the Americas and the Asia-Pacific region have shown significant underassessment of asthma severity in addition to undertreatment of asthma and have suggested the need to improve long-term asthma management. In this study, we examin...
  • Debates in allergy medicine: Specific immunotherapy in children with atopic dermatitis, the “con” view

    World Allergy Organization Journal

    David N. Ginsberg; Lawrence F. Eichenfield

    Atopic dermatitis (AD) is a common chronic skin condition in children that has a proven association with other atopic conditions and allergies. These associations, like the general pathophysiology of AD, are complex and not fully understood. While there is evidence for the efficacy of specific i...